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12 Gauge

$99.99

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ADVANCED 5 STAGE ANABOLIC ACTIVATOR

  • 30 Servings Per Container
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12 Gauge SFP

Packing on muscle isn’t just about crushing it in the gym – that is only part of the equation. We need to make sure that our body’ s anabolic hormones are maximized, so that those strength and mass gains go through the roof! That is why Kodiak Sports Nutrition is excited to present 12 GaugeTM: the most effective anabolic stimulator you can find (naturally). We utilize a 5 stage process to supercharge growth. First, bound testosterone must be freed from its inhibitory binding partner: sex hormone binding globulin. Second, free testosterone must also be boosted, independent of SHBG reduction. Third, we make sure to induce IGF-1 – a potent growth hormone. Fourth, myostatin is inhibited, since myostatin inhibits muscle growth. Fifth, we utilize activators of muscle protein synthesis. This multi-stage approach ensures that every major hormonal pathway is fine-tuned to stimulate long-lasting, maximal muscle growth!

  • Zinc and Boron – essential minerals that lower SHBG, so that bound testosterone can be freed and active
  • Vitamins B6 and D3 – essential vitamins that increase free testosterone
  • Maslinic acid – a compound from olives that boosts IGF-1 production
  • Epicatechin – found in dark chocolate, this catechin inhibits myostatin while activating its opposite: follistatin
  • Laxogenin – a brassinosteroid which induces muscle protein synthesis
  • Bioperine – the bioactive activator that slows metabolism to make this formula long-lasting and more effective

 

The standard has now been set – if your anabolic booster does not address multiple hormonal pathways, such as IGF-1, myostatin, and muscle protein synthesis, then we are talking apples to oranges. Let hunt those gains down and throw them in the back of the truck with the new king of anabolism: 12 GaugeTM.

Vitamin B6

Vitamin B6 is an essential vitamin that plays a role in various functions of the body, such as DNA repair and neurotransmitter synthesis.
• Vitamin B6 plays a role in testosterone synthesis and receptor availability
• B vitamin deficiency directly affects the liver’s ability to inactivate estrogen.

Vitamin D3

Vitamin D3 is not actually a vitamin, but is a steroid hormone with effects on thousands of functions in the body, including testosterone production.
• Multiple studies show that testosterone can be increased with D3 supplementation
• Vitamin D3 also lowers SHBG, which then leads to lower bound testosterone and higher free testosterone

Zinc

Zinc is an excellent complement to this formula, since it acts as an aromatase inhibitor, so it can decrease the conversion of testosterone to estrogen.
• Kilic et al. showed improved levels of testosterone and thyroid hormones in elite wrestlers after consuming zinc.
• Zinc lowers SHBG to enable more bound testosterone to become free and active testosterone

Boron

Boron is a trace mineral that is a must in any testosterone-boosting formula due to its proven results.
• Studies have shown that boron is able to boost total and free testosterone
• Since boron is also able to lower SHBG, then it is freeing up bound testosterone in the blood

Paederia Foetida

• Traditionally used in the Himalayas as an aphrodisiac, this compound demonstrates benefits on testosterone, sexual activity and sexual virility
• Halberstam et al. showed that testosterone increased significantly after consuming Paederia, accompanied by an increase in blood flow and sperm count

Fadogia Agrestis

Fadogia is a medicinal plant from east Africa that shows profound testosterone and sexual virility benefits
• Fadogia has been traditionally used to treat malaria and fevers due to its anti-inflammatory and antiplasmodial properties
• Yakubu et al. showed increases in testosterone, with increased sexual desire and increased ejaculatory latency

Epicatechin

Epicatechin is found in green tea and dark chocolate, and it has been shown to act as a myostatin inhibitor
• Gutierrez-Salmean et al. demonstrated that epicatechin supplementation significantly decreases myostatin and increases follistatin (which works in the opposite way as myostatin does)
• Multiple studies have shown that epicatechin reliably increases blood flow, which may help in the delivery of testosterone to its target tissues

5-Alpha-Hydroxy Laxogenin

Laxogenin is a plant brassinosteroid that can increase muscle mass and muscle protein synthesis via IGF-1 activation.
• Laxogenin is structurally similar to the anabolic steroid oxandrolone, which has demonstrated profound effects on muscle mass and strength
• Brassinosteroids have been shown to increase protein synthesis and reduce protein degradation via the PI3/Akt pathway

Maslinic Acid

Maslinic acid is a triterpenoid compound from olives that has benefits on muscle growth and protein synthesis
• Pentacyclic triterpenoids, like maslinic acid, have demonstrated muscle growth increases via IGF-1 activation
• Multiple studies have shown how maslinic acid increases protein turnover rates and growth in an animal model

Bioperine

Bioperine is a patented black pepper extract. Traditionally used for gastrointestinal disorders, it can prolong the effectiveness of the other compounds in the formula, such that the overall testosterone-boosting capability will be long-lasting and more effective.
• Bioperine has demonstrated increases of bioavailability of bioactive compounds of up to 2000%
• Bioperine downregulates enzymes that eliminate bioactive compounds from the body, such that their bioavailability is enhanced
• Bioperine increases absorption by decreasing intestinal motility rate, thereby allowing other bioactive compounds more time to be absorbed

Q: How do I take Kodiak 12 Gauge?
A: Take one serving (3 capsules) once daily in the morning.

Q: Is taking Kodiak 12 Gauge safe?
A: Yes, all the ingredients are vitamins, minerals, or botanicals. All ingredients have been carefully sourced and tested for safety, as well as the final formula.

Q: Are there steroids in Kodiak 12 Gauge?
A: No anabolic steroids were used in the formulating of 12 Gauge. Laxogenin is a brassinosteroid, which means that it is chemically similar to some anabolic steroids, but it is plant-derived from members of the Brassica family, such as mustard, broccoli, and cauliflower.

Q: What other Kodiak products can I stack with 12 Gauge?
A: Our Attack pre-workout, our Ammo intra, and our 3Whey protein for post-workout recovery would all stack well with 12 Gauge.

Q: When is the best time to take Kodiak 12 Gauge?
A: In the morning is best to take advantage of your body’s natural testosterone diurnal cycle.

Vitamin B6

1. BISKIND, M.S. and G.R. BISKIND, Inactivation of testosterone propionate in the liver during vitamin B complex deficiency. Alteration of the estrogen-androgen equilibrium. Endocrinology, 1943. 32(1): p. 97-102.
2. Biskind, M.S. and G.R. Biskind, Effect of vitamin B complex deficiency on inactivation of estrone in the liver. Endocrinology, 1942. 31(1): p. 109-114.
3. Symes, E.K., et al., Increased target tissue uptake of, and sensitivity to, testosterone in the vitamin B6 deficient rat. J Steroid Biochem, 1984. 20(5): p. 1089-93.

Vitamin D3
1. Wehr, E., et al., Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf), 2010. 73(2): p. 243-8.
2. Pilz, S., et al., Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res, 2011. 43(3): p. 223-5.
3. Bischoff-Ferrari, H.A., E.J. Orav, and B. Dawson-Hughes, Additive benefit of higher testosterone levels and vitamin D plus calcium supplementation in regard to fall risk reduction among older men and women. Osteoporos Int, 2008. 19(9): p. 1307-14.
4. Diamond, T., et al., Hip fracture in elderly men: the importance of subclinical vitamin D deficiency and hypogonadism. The Medical journal of Australia, 1998. 169(3): p. 138-141.
5. Nimptsch, K., et al., Association between plasma 25‐OH vitamin D and testosterone levels in men. Clinical endocrinology, 2012. 77(1): p. 106-112.
6. Kripke, D.F., et al., Weak evidence of bright light effects on human LH and FSH. Journal of circadian rhythms, 2010. 8(1): p. 5.

Zinc
1. Hammond, G.L., G.V. Avvakumov, and Y.A. Muller, Structure/function analyses of human sex hormone-binding globulin: effects of zinc on steroid-binding specificity. The Journal of steroid biochemistry and molecular biology, 2003. 85(2): p. 195-200.
2. Kilic, M., et al., The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc. Neuro Endocrinol Lett, 2006. 27(1-2): p. 247-52.
3. Kilic, M., Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc. Neuro Endocrinol Lett, 2007. 28(5): p. 681-5.

Boron
1. Ferrando, A.A. and N.R. Green, The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders. International journal of sport nutrition, 1993. 3(2): p. 140-149.
2. Naghii, M.R., et al., Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol, 2011. 25(1): p. 54-8.
3. Green, N.R. and A.A. Ferrando, Plasma boron and the effects of boron supplementation in males. Environmental health perspectives, 1994. 102(Suppl 7): p. 73.
4. Samman, S., et al., The nutritional and metabolic effects of boron in humans and animals. Biological trace element research, 1998. 66(1-3): p. 227-235.

Paederia Foetida
1. Halberstam, M., et al., Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes, 1996. 45(5): p. 659-66.
2. Osman, H., et al., Antioxidant activity and phenolic content of Paederia foetida and Syzygium aqueum. Molecules, 2009. 14(3): p. 970-8.
3. De, S., B. Ravishankar, and G.C. Bhavsar, Investigation of the anti-inflammatory effects of Paederia foetida. J Ethnopharmacol, 1994. 43(1): p. 31-8.

Fadogia Agrestis
1. Yakubu, M.T., M.A. Akanji, and A.T. Oladiji, Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats. Asian J Androl, 2005. 7(4): p. 399-404.
2. Anero, R., et al., Monoterpene glycosides isolated from Fadogia agrestis. Phytochemistry, 2008. 69(3): p. 805-11.
3. Sanon, S., et al., Ethnobotanical survey and in vitro antiplasmodial activity of plants used in traditional medicine in Burkina Faso. J Ethnopharmacol, 2003. 86(2-3): p. 143-7.

Epicatechin
1. Gutierrez-Salmean, G., et al., Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem, 2014. 25(1): p. 91-4.
2. Loffredo, L., et al., NOX2-mediated arterial dysfunction in smokers: acute effect of dark chocolate. Heart, 2011. 97(21): p. 1776-81.
3. Vlachopoulos, C., et al., Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens, 2005. 18(6): p. 785-91.
4. Grassi, D., et al., Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr, 2008. 138(9): p. 1671-6.

5-Alpha-Hydroxy Laxogenin
1. Schroeder, E.T., et al., Treatment with oxandrolone and the durability of effects in older men. J Appl Physiol (1985), 2004. 96(3): p. 1055-62.
2. Esposito, D., et al., Anabolic effect of plant brassinosteroid. The FASEB Journal, 2011. 25(10): p. 3708-3719.
3. Robey, R.B. and N. Hay. Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis. in Seminars in cancer biology. 2009. Elsevier.

Maslinic Acid
1. Fernández-Navarro, M., et al., Maslinic acid added to the diet increases growth and protein-turnover rates in the white muscle of rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2008. 147(2): p. 158-167.
2. Rufino‐Palomares, E.E., et al., The role of maslinic acid in the pentose phosphate pathway during growth of gilthead sea bream (Sparus Aurata). Aquaculture Nutrition, 2013. 19(5): p. 709-720.
3. Bagchi, D., S. Nair, and C.K. Sen, Nutrition and enhanced sports performance: Muscle building, endurance, and strength. 2013: Academic Press.

Bioperine
1. Bajad, S., et al., Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med, 2001. 67(2): p. 176-9.
2. Rao, V.R., et al., Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. Nat Prod Res, 2011. 25(13): p. 1288-94.
3. Shoba, G., et al., Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med, 1998. 64(4): p. 353-6.
4. Han, H.K., The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin Drug Metab Toxicol, 2011. 7(6): p. 721-9.